Orbital histiocytosis with systemic involvement: A case with complex affiliations.

A 70-year-old male presented with orbital masses affecting the muscular cone. His past medical history was notable for diabetes mellitus, ischemic cardiopathy, sleep-apnea syndrome, and multiple serous effusions. The first biopsy specimen of affected orbital tissue revealed fibrohistiocytic infiltration resembling xanthogranuloma or Erdheim-Chester disease (ECD). An ulterior biopsy of affected orbital tissue showed lymphocyte emperipolesis with immunopositivity for CD68 and S100 but negative staining for CD1a marker, strongly suggesting Rosai-Dorfman disease (RDD). Afterward, pericardium and peritoneal effusions resulted in constrictive pericarditis and retroperitoneal fibrosis, respectively. The absence of distinctive clinical features made the diagnosis especially challenging. Attempts to control the disease using corticosteroids, radiation, orbital surgery, and interferon were unsuccessful. Aggressive treatments such as chemotherapy were not considered appropriate due to the general deterioration of our patient. Although the possibility of two concurrent diseases (e.g., systemic ECD and orbital RDD) cannot be discarded, we interpreted the orbital findings as likely due to RDD, and the entire condition of our patient as an extranodal RDD with atypical clinicopathological findings and outcome.

A Pharmacist-Led Transitional Care Program to Reduce Hospital Readmissions in Older Adults.

Medication reconciliation and patient education during admission and after discharge helped older patients remain independent at home.

Impact of prealbumin on mortality and hospital readmission in patients with acute heart failure.

BACKGROUND: Prealbumin is a maker of nutritional status and inflammation of potential prognostic value in acute heart failure (HF). The aim of this study is to evaluate if low prealbumin levels on admission predict mortality and readmissions in patients with acute HF. METHOD: We conducted a prospective observational cohort study including 442 patients hospitalized for acute HF. Patients were classified in two groups according to prealbumin levels: "normal" prealbumin (>15mg) and "low" prealbumin (≤15mg/dL). End-points were mortality and readmissions (all-cause and HF-related) and the combined end-point of mortality/readmission at 180days. RESULTS: Out of 442 patients, 159 (36%) had low and 283 (64%) had normal prealbumin levels Mean age was 79.6 (73.9-84.2, p=0,405) years and 183 (41%, p=0,482) were males. After a median 180days of follow-up, 108 (24%, p=0,021) patients died and 170 (38%, p=0,067) were readmitted. Mortality was higher in the low prealbumin group. The combined end-point was more frequent in the low prealbumin group (57% vs. 50%, p=0.199). In the multivariate analysis the following variables were associated with mortality or readmission: older age, exacerbated chronic HF, higher comorbidity, low systolic blood pressure and hemoglobin values and higher pro brain natriuretic peptide levels. CONCLUSIONS: Low prealbumin is common (36%) in patients with acute heart failure and it is associated with a higher short-term mortality.

Basal functional status predicts three-month mortality after a heart failure hospitalization in elderly patients - the prospective RICA study.

BACKGROUND: Many elderly heart failure (HF) patients show some degree of functional impairment. The study aim was to evaluate the functional status of oldest-old cohort of patients hospitalized with a diagnosis of decompensated (HF), and to analyze whether preadmission functional status predicts risk of 3-month mortality. METHODS: We analyzed 1431 elderly (≥ 75 years) patients prospectively included in the Spanish National Registry on HF (RICA). We added Barthel Index (BI) to the usual HF patient assessment to measure patients' functional status, and we evaluated the relationship between preadmission BI values and 3-month mortality. RESULTS: The mean age of patients was 82.3 (4.6) years. Patients' mean preadmission BI score was 81.3 (21.5); 802 patients (55.9%) had BI scores <61. Multivariate analysis confirmed an independent association between poor preadmission BI and older age, female sex, higher comorbidity, cognitive impairment, previous institutionalization, worse New York Heart Association (NYHA) functional class and lack of beta-blocker use. A total of 210 patients died (14.7%) after 3 months of follow-up. Cox multivariate analyses found that higher preadmission BI is correlated with reduced all-cause, 3-month postdischarge mortality [hazard ratio (HR) 0.981; CI95% 0.975-0.986, p<0.001]. Other variables independently associated with 3-month mortality were male sex, lower body mass index, lower systolic blood pressure, a diagnosis of diabetes and chronic kidney disease, worse NYHA class and not receiving treatment with beta-blockers. CONCLUSIONS: Severe functional disability is present among more than half of older patients admitted because of a HF decompensation. For this population, preadmission BI is a strong predictor of short-term mortality.

Paradoja de la obesidad en la insuficiencia cardiaca. Resultados del Registro RICA / Paradox of obesity in heart failure: Results from the Spanish RICA Registry

Fundamento y objetivo: La obesidad es un factor de riesgo de insuficiencia cardiaca (IC). De forma paradójica se ha descrito que el índice de masa corporal (IMC) se asocia de forma inversa con la mortalidad. El objetivo de este estudio es analizar si existe relación entre el IMC y la mortalidad en una cohorte de pacientes con IC. Pacientes y método: Analizamos desde el Registro Nacional de Insuficiencia Cardiaca (RICA, estudio de cohortes multicéntrico y prospectivo) los pacientes admitidos de forma consecutiva por IC en servicios de Medicina Interna de hospitales españoles (entre marzo de 2008 y septiembre de 2009). Se clasificaron los pacientes según las categorías de IMC de la Organización Mundial de la Salud (OMS). Resultados: Se incluyeron 712 pacientes, 54% mujeres, con una media de edad de 77,3 años. La cardiopatía hipertensiva fue la causa más frecuente de IC, pero con diferencias según categoría de IMC, siendo la cardiopatía valvular más frecuente en pacientes con exceso de peso y la isquémica en pacientes con normopeso. La fracción de eyección media fue del 50,2% y mayor para categorías más altas de IMC. Los valores de péptidos natriuréticos fueron menores en los grupos con mayor IMC (p<0,05). La mortalidad global al año fue del 13,9% y significativamente menor con el aumento del IMC: en sujetos con normopeso 20,4%, en sobrepeso 14,7% y en aquellos con obesidad 8,5% (p<0,01). En el análisis multivariante el sobrepeso se asoció de forma independiente y significativa a un aumento en la mortalidad respecto a la obesidad: riesgo relativo (RR) 3,05 (intervalo de confianza del 95% [IC 95%] 1,24-7,54). Conclusiones: Un mayor IMC se asoció a menores valores de péptidos natriuréticos y a menor mortalidad

Background and objectives: Obesity is a risk factor for heart failure (HF). Paradoxically, it has been described that body mass index (BMI) is inversely associated with mortality. The aim of this study was to analyse the relationship between BMI and mortality in a cohort of patients with HF. Patients and methods: All patients included in the RICA Registry between March 2008 and September 2009 were analysed. RICA is a multicenter, prospective cohort study that includes patients admitted for decompensated HF in Spanish Internal Medicine Services. Patients were divided according to the WHO body weight categories.Results: 712 patients were included; 54% were women and mean age was 77.3 years. Hypertensive cardiopathy was the most common etiology of HF with some differences according to BMI categories, being valvular disease more frequent among obese and overweight patients and ischemic HF among normal weight patients. Mean left ventricle ejection fraction was 50.2% and it was higher among higher BMI categories. Natriuretic peptide levels were significantly lower among higher BMI categories (P<.05). Overall mortality after one-year of follow-up was 13.9% and it was significantly lower among higher BMI categories: normal BMI 20.4%, overweight 14.7% and obesity 8.5% (P<.01). In the multivariate analysis, overweight was significantly and independently associated with an increased mortality risk in comparison with obesity: RR 3.05 (IC95% 1.24-7.54).Conclusions: An increase in BMI was associated with lower levels of natriuretic peptides and lower mortality

[Paradox of obesity in heart failure: results from the Spanish RICA Registry]. / Paradoja de la obesidad en la insuficiencia cardiaca. Resultados del Registro RICA.

BACKGROUND AND OBJECTIVES: Obesity is a risk factor for heart failure (HF). Paradoxically, it has been described that body mass index (BMI) is inversely associated with mortality. The aim of this study was to analyse the relationship between BMI and mortality in a cohort of patients with HF. PATIENTS AND METHODS: All patients included in the RICA Registry between March 2008 and September 2009 were analysed. RICA is a multicenter, prospective cohort study that includes patients admitted for decompensated HF in Spanish Internal Medicine Services. Patients were divided according to the WHO body weight categories. RESULTS: 712 patients were included; 54% were women and mean age was 77.3 years. Hypertensive cardiopathy was the most common etiology of HF with some differences according to BMI categories, being valvular disease more frequent among obese and overweight patients and ischemic HF among normal weight patients. Mean left ventricle ejection fraction was 50.2% and it was higher among higher BMI categories. Natriuretic peptide levels were significantly lower among higher BMI categories (P<.05). Overall mortality after one-year of follow-up was 13.9% and it was significantly lower among higher BMI categories: normal BMI 20.4%, overweight 14.7% and obesity 8.5% (P<.01). In the multivariate analysis, overweight was significantly and independently associated with an increased mortality risk in comparison with obesity: RR 3.05 (IC95% 1.24-7.54). CONCLUSIONS: An increase in BMI was associated with lower levels of natriuretic peptides and lower mortality.

Microbiology and outcome of iliopsoas abscess in 124 patients.

To describe the microbiology and outcome of iliopsoas abscess (IPA) in a large case series, we analyzed 124 cases of IPA collected from 1990 through 2004 in 11 hospitals in Spain. Twenty-seven (21.8%) patients had primary and 97 (78.2%) had secondary IPA. The main sources of infection were bone (50.5%), gastrointestinal tract (24.7%), and urinary tract (17.5%). A definitive microbial diagnosis was achieved in 93 (75%) cases. Abscess culture was the most frequent procedure leading to microbial diagnosis, followed by blood cultures. Staphylococcus aureus, Escherichia coli, and Bacteroides species were the most frequent microbial causes: S. aureus was the most common organism in patients with primary abscesses (42.9%) and with abscesses of skeletal origin (35.2%), whereas E. coli was the leading organism in those with abscesses of urinary (61.5%) and gastrointestinal (42.1%) tracts. Mycobacterium tuberculosis was found in 15 patients, 4 of them associated with human immunodeficiency virus (HIV) infection. Twenty (21.5%) cases had polymicrobial infections; these were more common among patients with abscesses of gastrointestinal origin. Information on clinical outcome was available for 120 patients; 19 (15.8%) had a relapse and 6 (5%) died due to complications related to the IPA. Patients who died were older and more likely to have bacteremia and E. coli isolated from cultures. In conclusion, secondary IPA is more prevalent than primary IPA. Among those with secondary IPA, most abscesses are secondary to a skeletal source. A bacterial etiology can be identified in most cases. The overall prognosis of patients with this condition is good.

Self-reported changes in drug and alcohol use after becoming homeless.

OBJECTIVES: We identified substance use patterns and factors associated with increased substance use after users become homeless. METHODS: We carried out a 2-city, community-based survey that used population-proportionate sampling of 91 sites with random selection at each site. RESULTS: Five hundred thirty-one adults were interviewed; 78.3% of them met Diagnostic and Statistical Manual of Mental Disorders, Revised Third Edition criteria for substance abuse or dependence. Most of those who met the criteria reported using drugs and alcohol less since they became homeless, commonly because they were in recovery. Factors independently associated with increased use were no health insurance (odds ratio [OR] = 1.6; 95% confidence interval [CI] = 1.02, 2.58), alcohol abuse or dependence (OR = 3.5; 95% CI = 1.85, 6.78), and selling plasma (OR = 2.6; 95% CI = 1.32, 5.14) or panhandling (OR = 3.0; 95% CI = 1.65, 5.55) to acquire drugs. CONCLUSIONS: Becoming homeless plays a role in self-reported substance use. Multiservice treatment programs and tailored interventions for homeless persons are needed.

Rinitis crónica atrófica e infección por Klebsiella ozaenae / Chronic atrophic rhinitis and Klebsiella ozaenae infection

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